Dr. Nur Walker Pizarro
Department of Pediatrics Hospital Elizabeth Seton Clinica Copacabana Chile
Title: The Role of Probiotics in Preventing Neonatal Hyperbilirubinemia
Biography
Biography: Dr. Nur Walker Pizarro
Abstract
Neonatal jaundice is a common condition and an important cause of hospital admissions. This report reviews the efficacy of Lactobacillus reuteri and Saccharomyces boulardii in preventing high bilirubin levels and associated phototherapy admissions.
Methods and Materials:
This was a prospective, randomized study involving three groups. Group 1 was designated as a control and received no intervention. During the first four days of life, Group 2 received a concentrated dose of Lactobacillus reuteri while Group 3 received a concentrated dose of Saccharomyces boulardii. Bilirubinemia levels were assessed on day 4.
Results:
The sample size consisted of 98 subjects, including 36 in control Group 1, 31 in Group 2 and 31 in Group 3. Mean bilirubinemia at day 4 was 14.7 mg/dl in control Group 1, 13.8 mg/dl in Group 2, and 14.9 mg/dl in Group 3 (p>0.05). Group 2 accounted for the most subjects (45%) in the low to intermediate risk zone (LIRZ), compared to 30 percent in control Group 1 and 29 percent in Group 3. (p<0.05). Eight subjects required light therapy, including two in Group 2 and three in each of control Group 1 and Group 3. (p>0.05).
Conclusions: The use of probiotics to prevent neonatal hyperbilirubinemia or bring down phototherapy dmissions does not appear to be cost-effective.
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